Melanocortin 3 receptor

MC3R
Identifiers
Aliases	MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL, Melanocortin 3 receptor
External IDs	OMIM: 155540; MGI: 96929; HomoloGene: 7412; GeneCards: MC3R; OMA:MC3R - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	56,249,815 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,093,034 bp
RNA expression pattern
	Top expressed in
	deltoid muscle; ; hypothalamus; ; prefrontal cortex; ; sensory organ; ; mucosa of nose; ; superior frontal gyrus; ; olfactory zone of nasal mucosa; ; dorsolateral prefrontal cortex; ; wall of uterus; ; endometrium;
	Top expressed in
	embryo; ; gastrula; ; lumbar subsegment of spinal cord; ; meninges; ; arcuate nucleus; ; skin of abdomen; ; nucleus of stria terminalis; ; Region of wall of ventricular system of neuraxis; ; ventricular system; ; choroid plexus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; peptide hormone binding; melanocyte-stimulating hormone receptor activity; protein binding; melanocortin receptor activity; neuropeptide binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure;
Biological process	homoiothermy; rhythmic process; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; regulation of feeding behavior; circadian regulation of gene expression; regulation of heart rate; regulation of blood pressure; phospholipase C-activating G protein-coupled receptor signaling pathway; sodium ion homeostasis; signal transduction; locomotor rhythm; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4159
	17201
	ENSG00000124089
	ENSMUSG00000038537
	P41968
	P33033
	NM_019888
	NM_008561
	NP_063941
	NP_032587
	Wikidata
View/Edit Human	View/Edit Mouse

Melanocortin 3 receptor (MC₃R) is a protein that in humans is encoded by the MC3R gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124089 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038537 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (April 1993). "Molecular cloning of a novel melanocortin receptor". The Journal of Biological Chemistry. 268 (11): 8246–50. doi:10.1016/S0021-9258(18)53088-X. PMID 8463333.
^ "Entrez Gene: MC3R melanocortin 3 receptor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124089 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038537 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8463333-5] Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (April 1993). "Molecular cloning of a novel melanocortin receptor". The Journal of Biological Chemistry. 268 (11): 8246–50. doi:10.1016/S0021-9258(18)53088-X. PMID 8463333.

[entrez-6] "Entrez Gene: MC3R melanocortin 3 receptor".

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