Melatonin receptor 1B

MTNR1B
Identifiers
Aliases	MTNR1B, FGQTL2, MEL-1B-R, MT2, Melatonin receptor 1B
External IDs	OMIM: 600804; MGI: 2181726; HomoloGene: 4350; GeneCards: MTNR1B; OMA:MTNR1B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	92,985,066 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	15,785,852 bp
RNA expression pattern
	Top expressed in
	gonad; ; islet of Langerhans; ; nucleus accumbens; ; placenta; ; caudate nucleus; ; renal cortex; ; endometrium; ; left testis; ; right testis; ; hypothalamus;
	Top expressed in
	lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; melatonin receptor activity; protein binding; G protein-coupled receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	glucose homeostasis; regulation of insulin secretion; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; circadian rhythm; signal transduction; chemical synaptic transmission; G protein-coupled receptor signaling pathway; negative regulation of cGMP-mediated signaling; positive regulation of circadian rhythm; camera-type eye development; negative regulation of neuron apoptotic process; positive regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of insulin secretion; negative regulation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; positive regulation of transmission of nerve impulse; regulation of neuronal action potential; negative regulation of delayed rectifier potassium channel activity;
	Sources:Amigo / QuickGO
Orthologs
	4544
	244701
	ENSG00000134640
	ENSMUSG00000050901
	P49286
	Q8CIQ6; Q3SXF8
	NM_005959
	NM_145712
	NP_005950
	NP_663758
	Wikidata
View/Edit Human	View/Edit Mouse

Melatonin receptor 1B, also known as MTNR1B, is a protein that in humans is encoded by the MTNR1B gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134640 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050901 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MTNR1B melatonin receptor 1B".
^ Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF (Sep 1995). "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor". Proceedings of the National Academy of Sciences of the United States of America. 92 (19): 8734–38. Bibcode:1995PNAS...92.8734R. doi:10.1073/pnas.92.19.8734. PMC 41041. PMID 7568007.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134640 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050901 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MTNR1B melatonin receptor 1B".

[pmid7568007-6] Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF (Sep 1995). "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor". Proceedings of the National Academy of Sciences of the United States of America. 92 (19): 8734–38. Bibcode:1995PNAS...92.8734R. doi:10.1073/pnas.92.19.8734. PMC 41041. PMID 7568007.

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