Clinical data | |
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Trade names | Mobic, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601242 |
License data | |
Pregnancy category |
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Routes of administration | By mouth, intravenous |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | 89%[7] |
Protein binding | 99.4%[7] |
Metabolism | Liver (CYP2C9 and 3A4-mediated)[7] |
Elimination half-life | 20 hours[7] |
Excretion | Urine and feces equally[7] |
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PDB ligand | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.113.257 |
Chemical and physical data | |
Formula | C14H13N3O4S2 |
Molar mass | 351.40 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Meloxicam, sold under the brand name Mobic among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in rheumatic diseases and osteoarthritis.[8][9] It is used by mouth or by injection into a vein.[9][10] It is recommended that it be used for as short a period as possible and at a low dose.[9]
Common side effects include abdominal pain, dizziness, swelling, headache, and a rash.[9] Serious side effects may include heart disease, stroke, kidney problems, and stomach ulcers.[9] Use is not recommended in the third trimester of pregnancy.[9] It blocks cyclooxygenase-2 (COX-2) more than it blocks cyclooxygenase-1 (COX-1).[9] It is in the oxicam family of chemicals and is closely related to piroxicam.[9]
Meloxicam was patented in 1977 and approved for medical use in the United States in 2000.[9][11] It was developed by Boehringer Ingelheim; however, it is also available as a generic medication.[9] In 2022, it was the 29th most commonly prescribed medication in the United States, with more than 18 million prescriptions.[12][13] An intravenous version of meloxicam (Anjeso) was approved for medical use in the United States in February 2020.[14][10]
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