Merlin (protein)

NF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZRJ, 1H4R, 3U8Z, 4ZRI
Identifiers
Aliases	NF2, ACN, BANF, SCH, neurofibromin 2 (merlin), neurofibromin 2, merlin-1, moesin-ezrin-radixin like (MERLIN) tumor suppressor
External IDs	OMIM: 607379; MGI: 97307; HomoloGene: 2180; GeneCards: NF2; OMA:NF2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 29,603,556 bp[1] End 29,698,598 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 3.0 cM Start 4,715,845 bp[2] End 4,799,536 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium dorsal motor nucleus of vagus nerve tendon of biceps brachii Region I of hippocampus proper glutes postcentral gyrus vastus lateralis muscle triceps brachii muscle entorhinal cortex inferior olivary nucleus Top expressed in gastrula saccule otic vesicle neural layer of retina otic placode submandibular gland muscle of thigh secondary oocyte molar myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal protein binding protein binding actin binding Cellular component cytoplasm cell body cell projection membrane filopodium ruffle adherens junction plasma membrane apical part of cell ruffle membrane early endosome nucleolus cortical actin cytoskeleton perinuclear region of cytoplasm neuron projection cleavage furrow cytoskeleton nucleus lamellipodium filopodium membrane cytosol Biological process negative regulation of receptor signaling pathway via JAK-STAT regulation of gliogenesis cell-cell junction organization regulation of protein stability negative regulation of cell-cell adhesion negative regulation of protein kinase activity mesoderm formation ectoderm development negative regulation of DNA replication Schwann cell proliferation regulation of neural precursor cell proliferation regulation of protein localization to nucleus negative regulation of cell-matrix adhesion odontogenesis of dentin-containing tooth brain development negative regulation of cell migration lens fiber cell differentiation regulation of cell population proliferation positive regulation of cell differentiation negative regulation of MAPK cascade regulation of hippo signaling hippocampus development regulation of stem cell proliferation regulation of neurogenesis actin cytoskeleton organization positive regulation of stress fiber assembly negative regulation of cell population proliferation negative regulation of tyrosine phosphorylation of STAT protein regulation of apoptotic process regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4771 18016 Ensembl ENSG00000186575 ENSMUSG00000009073 UniProt P35240 P46662 RefSeq (mRNA) NM_181835 NM_000268 NM_016418 NM_181825 NM_181826 NM_181827 NM_181828 NM_181829 NM_181830 NM_181831 NM_181832 NM_181833 NM_181834 NM_001252250 NM_001252251 NM_001252252 NM_001252253 NM_010898 NM_001361675 NM_001361676 NM_001361677 RefSeq (protein) NP_000259 NP_057502 NP_861546 NP_861966 NP_861967 NP_861968 NP_861969 NP_861970 NP_861971 NP_001239179 NP_001239180 NP_001239181 NP_001239182 NP_035028 NP_001348604 NP_001348605 NP_001348606 Location (UCSC) Chr 22: 29.6 – 29.7 Mb Chr 11: 4.72 – 4.8 Mb PubMed search [3] [4]
Wikidata
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Merlin (also called neurofibromin 2 or schwannomin) is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in neurofibromatosis type II.^[5][6] Sequence data reveal its similarity to the ERM protein family.

The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein".