Metabolon

In biochemistry, a metabolon is a temporary structural-functional complex formed between sequential enzymes of a metabolic pathway, held together both by non-covalent interactions and by structural elements of the cell, such as integral membrane proteins and proteins of the cytoskeleton.

The formation of metabolons allows the intermediate product from one enzyme to be passed (channelling) directly into the active site of the next consecutive enzyme of the metabolic pathway. The citric acid cycle is an example of a metabolon that facilitates substrate channeling.[1][2] Another example is the dhurrin synthesis pathway in sorghum, in which the enzymes assemble as a metabolon in lipid membranes.[3] During the functioning of metabolons, the amount of water needed to hydrate the enzymes is reduced and enzyme activity is increased[citation needed].

  1. ^ Wu, Fei; Minteer, Shelley (2 February 2015). "Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross-Linking and Mass Spectrometry". Angewandte Chemie International Edition. 54 (6): 1851–1854. doi:10.1002/anie.201409336. PMID 25537779.
  2. ^ Zhang, Youjun; Beard, Katherine F. M.; Swart, Corné; Bergmann, Susan; Krahnert, Ina; Nikoloski, Zoran; Graf, Alexander; Ratcliffe, R. George; Sweetlove, Lee J.; Fernie, Alisdair R.; Obata, Toshihiro (16 May 2017). "Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle". Nature Communications. 8: 15212. doi:10.1038/ncomms15212. PMC 5440813. PMID 28508886.
  3. ^ Laursen, Tomas; Borch, Jonas; Knudsen, Camilla; Bavishi, Krutika; Torta, Federico; Martens, Helle Juel; Silvestro, Daniele; Hatzakis, Nikos S.; Wenk, Markus R. (2016-11-18). "Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum" (PDF). Science. 354 (6314): 890–893. doi:10.1126/science.aag2347. ISSN 0036-8075. PMID 27856908. S2CID 19187608.