Metabotropic glutamate receptor 3 (mGluR3) is an inhibitory Gi/G0-coupledG-protein coupled receptor (GPCR)[4] generally localized to presynaptic sites of neurons in classical circuits.[5] However, in higher cortical circuits in primates, mGluR3 are localized post-synaptically, where they strengthen rather than weaken synaptic connectivity.[6] In humans, mGluR3 is encoded by the GRM3gene.[7][8] Deficits in mGluR3 signaling have been linked to impaired cognition in humans,[9] and to increased risk of schizophrenia,[10] consistent with their expanding role in cortical evolution.
^Zink CF, Barker PB, Sawa A, Weinberger DR, Wang M, Quillian H, Ulrich WS, Chen Q, Jaffe AE, Kleinman JE, Hyde TM, Prettyman GE, Giegerich M, Carta K, van Ginkel M, Bigos KL (December 2020). "Association of Missense Mutation in FOLH1 With Decreased NAAG Levels and Impaired Working Memory Circuitry and Cognition". The American Journal of Psychiatry. 177 (12): 1129–1139. doi:10.1176/appi.ajp.2020.19111152. PMID33256444. S2CID227243375.