Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene.[5][6][7]
Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of the cyclic AMP cascade.[7] Activation of GRM4 has potential therapeutic benefits in the treatment of parkinson's disease. Splice variant "taste-GRM4" is involved in the perception of umami taste.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000124493 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063239 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Makoff A, Lelchuk R, Oxer M, Harrington K, Emson P (April 1996). "Molecular characterization and localization of human metabotropic glutamate receptor type 4". Brain Research. Molecular Brain Research. 37 (1–2): 239–248. doi:10.1016/0169-328X(95)00321-I. PMID 8738157.
- ^ Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, et al. (January 1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Research. Molecular Brain Research. 53 (1–2): 88–97. doi:10.1016/S0169-328X(97)00277-5. PMID 9473604.
- ^ a b "Entrez Gene: GRM4 glutamate receptor, metabotropic 4".
- ^ Chaudhari N, Landin AM, Roper SD (February 2000). "A metabotropic glutamate receptor variant functions as a taste receptor". Nature Neuroscience. 3 (2): 113–119. doi:10.1038/72053. PMID 10649565. S2CID 16650588.