Metabotropic glutamate receptor 5

GRM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LMK, 4OO9, 5CGC, 5CGD
Identifiers
Aliases	GRM5, GPRC1E, MGLUR5, PPP1R86, mGlu5, glutamate metabotropic receptor 5
External IDs	OMIM: 604102; MGI: 1351342; HomoloGene: 37354; GeneCards: GRM5; OMA:GRM5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.2-q14.3 Start 88,504,576 bp[1] End 89,065,982 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 87,233,376 bp[2] End 87,784,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell buccal mucosa cell Brodmann area 10 Brodmann area 46 postcentral gyrus orbitofrontal cortex Brodmann area 23 superior frontal gyrus Region I of hippocampus proper frontal pole Top expressed in lateral septal nucleus olfactory tubercle nucleus accumbens subiculum amygdala anterior amygdaloid area lumbar subsegment of spinal cord globus pallidus subdivision of hippocampus Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutamate receptor activity G protein-coupled receptor activity signal transducer activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration protein binding protein tyrosine kinase activator activity protein tyrosine kinase binding Cellular component cytoplasm integral component of membrane neuron projection plasma membrane integral component of plasma membrane extracellular exosome postsynaptic density membrane presynaptic membrane Schaffer collateral - CA1 synapse postsynaptic density membrane Biological process phospholipase C-activating G protein-coupled glutamate receptor signaling pathway G protein-coupled glutamate receptor signaling pathway G protein-coupled receptor signaling pathway regulation of long-term neuronal synaptic plasticity learning cognition locomotory behavior signal transduction chemical synaptic transmission regulation of synaptic transmission, glutamatergic adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway regulation of postsynaptic membrane potential regulation of postsynaptic cytosolic calcium ion concentration regulation of protein phosphorylation regulation of translation regulation of translational elongation learning or memory calcium-mediated signaling using intracellular calcium source synapse organization positive regulation of protein tyrosine kinase activity postsynaptic modulation of chemical synaptic transmission trans-synaptic signaling by endocannabinoid, modulating synaptic transmission regulation of intracellular calcium activated chloride channel activity cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2915 108071 Ensembl ENSG00000168959 ENSMUSG00000049583 UniProt P41594 Q3UVX5 RefSeq (mRNA) NM_000842 NM_001143831 NM_001384268 NM_001033224 NM_001081414 NM_001143834 RefSeq (protein) NP_000833 NP_001137303 NP_001074883 NP_001137306 Location (UCSC) Chr 11: 88.5 – 89.07 Mb Chr 7: 87.23 – 87.78 Mb PubMed search [3] [4]
Wikidata
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Metabotropic glutamate receptor 5 is an excitatory G_q-coupled G protein-coupled receptor^[5] predominantly expressed on the postsynaptic sites of neurons.^[6] In humans, it is encoded by the GRM5 gene.^[7][8]