Metabotropic glutamate receptor 7

GRM7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MQ4, 5C5C
Identifiers
Aliases	GRM7, GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87, glutamate metabotropic receptor 7, NEDSHBA
External IDs	OMIM: 604101; MGI: 1351344; HomoloGene: 20233; GeneCards: GRM7; OMA:GRM7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	7,741,533 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	111,544,191 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Region I of hippocampus proper; ; Brodmann area 23; ; entorhinal cortex; ; olfactory zone of nasal mucosa; ; sperm; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	medial dorsal nucleus; ; superior colliculus; ; mammillary body; ; olfactory tubercle; ; medial geniculate nucleus; ; piriform cortex; ; subiculum; ; ventromedial nucleus; ; substantia nigra; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; calcium ion binding; PDZ domain binding; serine binding; G protein-coupled receptor activity; group III metabotropic glutamate receptor activity; adenylate cyclase inhibitor activity; signal transducer activity; glutamate binding; calcium channel regulator activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; receptor complex; plasma membrane; integral component of plasma membrane; dendritic shaft; presynaptic active zone; axon; dendrite; cell cortex; asymmetric synapse; presynaptic membrane;
Biological process	negative regulation of glutamate secretion; response to stimulus; hearing; behavioral fear response; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; signal transduction; regulation of cyclase activity; regulation of synaptic transmission, glutamatergic; chemical synaptic transmission; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2917
	108073
	ENSG00000196277
	ENSMUSG00000056755
	Q14831
	Q68ED2
	NM_000844; NM_181874; NM_181875
	NM_177328; NM_001346640; NM_177970
	NP_000835; NP_870989
	NP_001333569; NP_796302
	Wikidata
View/Edit Human	View/Edit Mouse

Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196277 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056755 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (January 1994). "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction". The Journal of Biological Chemistry. 269 (2): 1231–1236. doi:10.1016/S0021-9258(17)42247-2. hdl:2433/182290. PMID 8288585.
^ Makoff A, Pilling C, Harrington K, Emson P (August 1996). "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS". Brain Research. Molecular Brain Research. 40 (1): 165–170. doi:10.1016/0169-328X(96)00110-6. PMID 8840028.
^ "Entrez Gene: GRM7 glutamate receptor, metabotropic 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196277 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056755 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8288585-5] Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (January 1994). "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction". The Journal of Biological Chemistry. 269 (2): 1231–1236. doi:10.1016/S0021-9258(17)42247-2. hdl:2433/182290. PMID 8288585.

[pmid8840028-6] Makoff A, Pilling C, Harrington K, Emson P (August 1996). "Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS". Brain Research. Molecular Brain Research. 40 (1): 165–170. doi:10.1016/0169-328X(96)00110-6. PMID 8840028.

[entrez-7] "Entrez Gene: GRM7 glutamate receptor, metabotropic 7".

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