Metabotropic glutamate receptor 8

GRM8
Identifiers
Aliases	GRM8, GLUR8, GPRC1H, MGLUR8, mGlu8, glutamate metabotropic receptor 8
External IDs	OMIM: 601116; MGI: 1351345; HomoloGene: 654; GeneCards: GRM8; OMA:GRM8 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	127,253,093 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,135,177 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; left testis; ; right testis; ; oocyte; ; Epithelium of choroid plexus; ; prefrontal cortex; ; Brodmann area 9; ; corpus callosum; ; cingulate gyrus;
	Top expressed in
	ganglion cell layer; ; secondary oocyte; ; zygote; ; inner nuclear layer; ; superior frontal gyrus; ; embryo; ; primary visual cortex; ; embryo; ; outer nuclear layer; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	glutamate receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; integral component of plasma membrane; presynaptic membrane; membrane; plasma membrane;
Biological process	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; signal transduction; visual perception; response to stimulus; regulation of synaptic transmission, glutamatergic; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2918
	14823
	ENSG00000179603
	ENSMUSG00000024211
	O00222
	P47743
NM_000845; NM_001127323; NM_001371083; NM_001371084; NM_001371085;
	NM_001371086; NM_001371087; NM_001371088
	NM_008174; NM_001311072; NM_001361125
NP_000836; NP_001120795; NP_001358012; NP_001358013; NP_001358014;
	NP_001358015; NP_001358016; NP_001358017
	NP_001298001; NP_032200; NP_001348054
	Wikidata
View/Edit Human	View/Edit Mouse

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179603 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (January 1996). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics. 31 (2): 230–233. doi:10.1006/geno.1996.0036. PMID 8824806.
^ "Entrez Gene: GRM8 glutamate receptor, metabotropic 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179603 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024211 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8824806-5] Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (January 1996). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics. 31 (2): 230–233. doi:10.1006/geno.1996.0036. PMID 8824806.

[entrez-6] "Entrez Gene: GRM8 glutamate receptor, metabotropic 8".

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