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In biochemistry, an N-methylamide (NME) is a blocking group for the C-terminus end of peptides. When the carboxyl group of the C-terminus is replaced with a methylamide, further elongation of the peptide chain is prevented. C-Terminal modified peptides are also useful for the modulation of structure-activity relationships and for modifying conformational properties of peptides. N-Methylamides can be prepared directly from solid phase resin-bound peptides.[1]
- ^ Ajayaghosh, A.; Pillai, V. N. Rajasekharan (1996). "Photo-triggered selective C-terminal N-methylamidative cleavage of polyethylene glycol-bound peptides". Tetrahedron Letters. 37 (35): 6421–6424. doi:10.1016/0040-4039(96)01363-9.