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Mfuwe is the main settlement of South Luangwa National Park in the Eastern Province of Zambia, serving the tourism industry and wildlife conservation in the Luangwa Valley. It is located in Mambwe District, about 100 km (62 mi) west-north-west of Chipata.
Mfuwe has an airport with a 2.15 km (1.34 mi) surfaced runway capable of taking regional domestic and international flights.
This village holds the record of the highest temperature ever recorded in Zambia with 42.8 °C (109.0 °F) set on 26 October 2011.
In 1991, the village was plagued by a large, maneless, man-eating lion later known as the Man-Eater of Mfuwe, who claimed six people before being shot and killed.