| miR-27 | |
|---|---|
 Conserved secondary structure of miR-27 prescursor | |
| Identifiers | |
| Symbol | miR-27 |
| Rfam | RF00644 |
| miRBase | MI0000085 |
| miRBase family | MIPF0000036 |
| NCBI Gene | 407018 |
| HGNC | 31613 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Animalia |
| Locus | Chr. 19 [1] |
| PDB structures | PDBe |
miR-27 is a family of microRNA precursors found in animals, including humans.[1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.[2] The excised region or, mature product, of the miR-27 precursor is the microRNA mir-27.
Herpesvirus saimiri expresses several non-coding RNAs (HSURs) which have been found to significantly reduce the level of mir-27 in a host cell.[3] It has been proposed that miR-27 operates together with miR-23 and mir-24 in a co-operative cluster.[4]
- ^ Landgraf, P; Rusu, M; Sheridan, R; Sewer, A; Iovino, N; Aravin, A; Pfeffer, S; Rice, A; et al. (Jun 29, 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–14. doi:10.1016/j.cell.2007.04.040. PMC 2681231. PMID 17604727.
- ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. S2CID 14574186.
- ^ Cazalla, D; Yario, T; Steitz, JA (Jun 18, 2010). "Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA". Science. 328 (5985): 1563–6. Bibcode:2010Sci...328.1563C. doi:10.1126/science.1187197. PMC 3075239. PMID 20558719.
- ^ Chhabra, R; Dubey, R; Saini, N (Sep 3, 2010). "Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases". Molecular Cancer. 9: 232. doi:10.1186/1476-4598-9-232. PMC 2940846. PMID 20815877.