| mir-2 microRNA precursor | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-2 | |
| Identifiers | |
| Symbol | mir-2 |
| Rfam | RF00047 |
| miRBase | MI0000117 |
| miRBase family | MIPF0000049 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
The mir-2 microRNA family includes the microRNA genes mir-2 and mir-13 (MIPF0000049). Mir-2 is widespread in invertebrates, and it is the largest family of microRNAs in the model species Drosophila melanogaster. MicroRNAs from this family are produced from the 3' arm of the precursor hairpin.[1] Leaman et al. showed that the miR-2 family regulates cell survival by translational repression of proapoptotic factors.[2] Based on computational prediction of targets, a role in neural development and maintenance has been suggested.[1]
- ^ a b Marco A, Hooks K, Griffiths-Jones S (March 2012). "Evolution and function of the extended miR-2 microRNA family". RNA Biology. 9 (3): 242–8. doi:10.4161/rna.19160. PMC 3384581. PMID 22336713.
- ^ Leaman D, Chen PY, Fak J, Yalcin A, Pearce M, Unnerstall U, Marks DS, Sander C, Tuschl T, Gaul U (July 2005). "Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development". Cell. 121 (7): 1097–108. doi:10.1016/j.cell.2005.04.016. hdl:11858/00-001M-0000-0012-EB54-F. PMID 15989958. S2CID 2463749.