Missing heritability problem

The missing heritability problem[1][2][3][4][5][6] arises from the difference between heritability estimates from genetic data and heritability estimates from twin and family data across many physical and mental traits, including diseases, behaviors, and other phenotypes. This is a problem that has significant implications for medicine, since a person's susceptibility to disease may depend more on the combined effect of all the genes in the background than on the disease genes in the foreground, or the role of genes may have been severely overestimated.

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  3. ^ Lee, S. H.; Wray, N. R.; Goddard, M. E.; Visscher, P. M. (2011). "Estimating Missing Heritability for Disease from Genome-wide Association Studies". American Journal of Human Genetics. 88 (3): 294–305. doi:10.1016/j.ajhg.2011.02.002. PMC 3059431. PMID 21376301.
  4. ^ Slatkin, M. (2009). "Epigenetic Inheritance and the Missing Heritability Problem". Genetics. 182 (3): 845–850. doi:10.1534/genetics.109.102798. PMC 2710163. PMID 19416939.
  5. ^ Eichler, E. E.; Flint, J.; Gibson, G.; Kong, A.; Leal, S. M.; Moore, J. H.; Nadeau, J. H. (2010). "Missing heritability and strategies for finding the underlying causes of complex disease". Nature Reviews Genetics. 11 (6): 446–450. doi:10.1038/nrg2809. PMC 2942068. PMID 20479774.
  6. ^ Maher, Brendan (2008). "Personal genomes: The case of the missing heritability". Nature. 456 (7218): 18–21. doi:10.1038/456018a. PMID 18987709.