Missouri Route 22

Route 22
Route information
Maintained by MoDOT
Length	28.797 mi[1] (46.344 km)
Existed	1922–present
Major junctions
West end	US 63 / Route F south of Clark
East end	US 54 / US 54 Bus. / Route 15 in Mexico
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 21 → Route 23

Route 22 is a highway in central Missouri. Its eastern terminus is at U.S. Route 54 in Mexico; its western terminus is at U.S. Route 63 south of Clark on the Randolph/Boone county line. Route 22 was one of the original 1922 state highways and originally had an eastern terminus at Route 9 (now U.S. Route 61) in Louisiana. This section was replaced by U.S. Route 54 in 1926.