Mitochondrial ribosome

A diagram showing mtDNA (circular) and mitochondrial ribosomes among other mitochondria structures

The mitochondrial ribosome, or mitoribosome, is a protein complex that is active in mitochondria and functions as a riboprotein for translating mitochondrial mRNAs encoded in mtDNA. The mitoribosome is attached to the inner mitochondrial membrane.[1] Mitoribosomes, like cytoplasmic ribosomes, consist of two subunits — large (mt-LSU) and small (mt-SSU).[2] Mitoribosomes consist of several specific proteins and fewer rRNAs.[2] While mitochondrial rRNAs are encoded in the mitochondrial genome, the proteins that make up mitoribosomes are encoded in the nucleus and assembled by cytoplasmic ribosomes before being implanted into the mitochondria.[3]

  1. ^ Cite error: The named reference :02 was invoked but never defined (see the help page).
  2. ^ a b Amunts A, Brown A, Toots J, Scheres SH, Ramakrishnan V (April 2015). "Ribosome. The structure of the human mitochondrial ribosome". Science. 348 (6230): 95–98. doi:10.1126/science.aaa1193. PMC 4501431. PMID 25838379.
  3. ^ Sylvester JE, Fischel-Ghodsian N, Mougey EB, O'Brien TW (March 2003). "Mitochondrial ribosomal proteins: candidate genes for mitochondrial disease". Genetics in Medicine. 6 (2): 73–80. doi:10.1097/01.GIM.0000117333.21213.17. PMID 15017329. S2CID 22169585.