Mitogen-activated protein kinase 9

MAPK9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E7O, 3NPC
Identifiers
Aliases	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK, mitogen-activated protein kinase 9
External IDs	OMIM: 602896; MGI: 1346862; HomoloGene: 55685; GeneCards: MAPK9; OMA:MAPK9 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	180,292,099 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	49,777,248 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; cerebellar cortex; ; cerebellar hemisphere; ; superior frontal gyrus; ; prefrontal cortex; ; pons; ; lateral nuclear group of thalamus; ; right hemisphere of cerebellum; ; dorsolateral prefrontal cortex;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; atrioventricular valve; ; cerebellar cortex; ; superior frontal gyrus; ; parotid gland; ; medial vestibular nucleus; ; submandibular gland; ; lateral hypothalamus; ; ventral tegmental area; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; MAP kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; transcription factor binding; JUN kinase activity; protein serine/threonine/tyrosine kinase activity;
Cellular component	cytosol; nucleoplasm; mitochondrion; nucleus; cytoplasm; neuron projection;
Biological process	response to cadmium ion; phosphorylation; rhythmic process; positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; Fc-epsilon receptor signaling pathway; protein phosphorylation; positive regulation of macrophage derived foam cell differentiation; positive regulation of gene expression; JUN phosphorylation; regulation of circadian rhythm; JNK cascade; response to mechanical stimulus; positive regulation of apoptotic process; neuron development; cellular response to organic substance; protein localization to tricellular tight junction; cellular response to reactive oxygen species; cellular response to cadmium ion; peptidyl-serine phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription factor catabolic process; regulation of gene expression; intracellular signal transduction; regulation of DNA-binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	5601
	26420
	ENSG00000050748
	ENSMUSG00000020366
	P45984
	Q9WTU6
NM_001135044; NM_001308244; NM_002752; NM_139068; NM_139069;
	NM_139070; NM_001364607; NM_001364608; NM_001364609; NM_001364610; NM_001364611; NM_001364612; NM_001364613
	NM_001163671; NM_001163672; NM_016961; NM_207692
NP_001128516; NP_001295173; NP_002743; NP_620707; NP_620708;
	NP_620709; NP_001351536; NP_001351537; NP_001351538; NP_001351539; NP_001351540; NP_001351541; NP_001351542
	NP_001157143; NP_001157144; NP_058657; NP_997575
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000050748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020366 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M (Dec 1994). "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes & Development. 8 (24): 2996–3007. doi:10.1101/gad.8.24.2996. PMID 8001819.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000050748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020366 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8001819-5] Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M (Dec 1994). "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation". Genes & Development. 8 (24): 2996–3007. doi:10.1101/gad.8.24.2996. PMID 8001819.

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