Mitomycin C

Mitomycin C
Skeletal formula
Ball-and-stick model of the molecular structure determined by X-ray crystallography[1]
Clinical data
Trade namesMitosol, Mutamycin, Jelmyto
Other namesUGN-101
AHFS/Drugs.comMonograph
MedlinePlusa682415
License data
Pregnancy
category
Routes of
administration		Intravenous, topical
Drug classAntineoplastic agent
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
Elimination half-life8–48 min
Identifiers
  • {11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate
CAS Number
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.008 Edit this at Wikidata
Chemical and physical data
FormulaC15H18N4O5
Molar mass334.332 g·mol−1
3D model (JSmol)
Melting point360 °C (680 °F)
Solubility in water8.43 g L−1
  • CO[C@@]12[C@H](COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1C[C@@H]1N[C@@H]12
  • InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 checkY
  • Key:NWIBSHFKIJFRCO-WUDYKRTCSA-N

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity.

  1. ^ Reiss GJ (2011). "KUWQIF: Mitomycin C Dihydrate, also known as (6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate dihydrate". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. doi:10.5517/ccdc.csd.cc12bt29. Archived from the original on 19 November 2021. Retrieved 3 November 2021.
  2. ^ "Mitomycin (Mutamycin) Use During Pregnancy". Drugs.com. 19 August 2019. Archived from the original on 22 October 2020. Retrieved 15 April 2020.
  3. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  4. ^ "Mitocin mitomycin 20 mg powder for injection vial (370360)". Therapeutic Goods Administration (TGA). 12 August 2022. Archived from the original on 18 March 2023. Retrieved 29 April 2023.
  5. ^ "Mitocin (Echo Therapeutics Pty Ltd)". Therapeutic Goods Administration (TGA). 28 September 2022. Archived from the original on 18 March 2023. Retrieved 29 April 2023.