Modified vaccinia Ankara

Modified vaccinia Ankara
Vaccine description
TargetSmallpox, mpox
Vaccine typeAttenuated
Clinical data
Trade namesImvanex, Imvamune, Jynneos
Other namesMVA
AHFS/Drugs.comProfessional Drug Facts
Routes of
administration		Subcutaneous, Intradermal[1]
ATC code
Legal status
Legal status
Identifiers
ChemSpider
  • none

Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. It is being used as a vaccine (called MVA-BN, brand names: Imvanex in the EU,[3] Imvamune in Canada,[2] and Jynneos in the US[1]) against smallpox and mpox,[4] having fewer side effects than smallpox vaccines derived from other poxviruses.[5]

This third-generation smallpox vaccine has the advantage that it cannot reproduce complete virions in human cells, "the block of the MVA life cycle occurs at the step of virion assembly resulting in assembly of immature virus particles that are not released from the infected cell."[5]

By inserting antigen genes into its genome, modified vaccinia Ankara virus is also used as an experimental viral vector for vaccines against non-poxvirus diseases.[6]

  1. ^ a b c "Jynneos- vaccinia virus modified strain ankara-bavarian nordic non-replicating antigen injection, suspension". DailyMed. 14 February 2022. Archived from the original on 27 May 2022. Retrieved 26 May 2022.
  2. ^ a b "Product Monograph including Patient Medication Information - Imvamune" (PDF). 26 November 2021. Archived (PDF) from the original on 26 May 2022. Retrieved 19 June 2022.
  3. ^ a b "Imvanex EPAR". European Medicines Agency (EMA). Archived from the original on 27 April 2022. Retrieved 2 October 2014.
  4. ^ "NACI Rapid Response - Interim guidance on the use of Imvamune in the context of monkeypox outbreaks in Canada" (PDF). Public Health Agency of Canada. June 2022. Archived (PDF) from the original on 19 June 2022. Retrieved 19 June 2022.
  5. ^ a b Cite error: The named reference Volz was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference :0 was invoked but never defined (see the help page).