Moriguchi (written: 森口 lit. "forest mouth") is a Japanese surname. Notable people with the surname include:
- Denise Moriguchi (born 1976), American businesswoman
- Fujimatsu Moriguchi (森口 富士松, 1898–1962), Japanese businessman
- Hiroko Moriguchi (森口 博子, born 1968), Japanese singer
- Kakō Moriguchi (森口 華弘, 1909–2008), Japanese textile artist
- Kunihiko Moriguchi (森口 邦彦, born 1941), Japanese textile artist
- Sadako Moriguchi (森口 貞子, 1907–2002), American businesswoman
- Tomio Moriguchi (森口 富雄, born 1936), American businessman and activist
- Yoko Moriguchi (森口 瑤子, born 1966), Japanese actress
- Yuko Moriguchi (森口 祐子, born 1955), Japanese golfer