Mortal Kombat 2 refers to several entries in the Mortal Kombat franchise:
- Mortal Kombat II, an arcade fighting video game first released in 1993, sequel to the original Mortal Kombat game
- Mortal Kombat Annihilation, a 1997 martial arts action movie based on the Mortal Kombat franchise, the second film in the 1990s Mortal Kombat film series
- Mortal Kombat 2 (film), an upcoming film based on the Mortal Kombat franchise, the second film in the 2020s Mortal Kombat film series
- Mortal Kombat volume 2 or issue 2, several different books; see List of Mortal Kombat media