| Mother Brain | |
|---|---|
| Metroid character | |
 Mother Brain in Metroid: Zero Mission | |
| First appearance | Metroid (1986) |
| Created by | Gunpei Yokoi |
| Designed by | Yoshio Sakamoto |
| Voiced by | Levi Stubbs (Captain N: The Game Master) |
| In-universe information | |
| Species | Cybernetic supercomputer (instilled with human DNA) |
Mother Brain (Japanese: マザーブレイン, Hepburn: Mazā Burein) is a fictional character created by Nintendo for the Metroid series. She is one of the most prominent antagonists within the series, serving as the main antagonist of Metroid and Super Metroid.
Mother Brain has been killed multiple times by series protagonist Samus Aran. Her Super Metroid design was originally milder than its final version, resembling an "old lady living in an apartment complex" when designed by Toru Osawa. This design was altered by Tomomi Yamane, who gave her an overall more monstrous appearance. She takes the form of a large brain that sits within a jar, from which she controls the Space Pirates on the fictional planet Zebes. Since Super Metroid (1994), she has had a single large eye.
Mother Brain has made several appearances in other media, most notably as the primary antagonist in Captain N: The Game Master and archenemy of Kevin Keene. Since appearing in the Metroid series, she has received positive reception.