Mouse brain

Mouse brain, lateral view

The mouse brain refers to the brain of Mus musculus. Various brain atlases exist.

For reasons of reproducibility, genetically characterized, stable strains like C57BL/6 were chosen to produce high-resolution images and databases.[1] Well known online resources include:

Despite superficial differences, especially in size and weight, the mouse brain and its function can serve as a powerful animal model for study of human brain diseases or mental disorders (see e.g. Reeler, Chakragati mouse). This is because the genes responsible for building and operating both mouse and human brain are 90% identical.[4] Transgenic mouse lines also allow neuroscientists to specifically target the labeling of certain cell types to probe the neural basis of fundamental processes.[5][6]

  1. ^ MacKenzie-Graham, Allan; Jones, Eagle S.; Shattuck, David W.; Dinov, Ivo D.; Bota, Mihail; Toga, Arthur W. (2003). "The Informatics of a C57BL/6J Mouse Brain Atlas". Neuroinformatics. 1 (4). Springer Nature: 397–410. doi:10.1385/ni:1:4:397. ISSN 1539-2791. PMID 15043223. S2CID 81057.
  2. ^ "ISH Data :: Allen Brain Atlas: Mouse Brain". ISH Data. Retrieved 2019-02-07.
  3. ^ "Search the library". The Mouse Brain Library. 2003-06-05. Retrieved 2019-02-07.
  4. ^ Park, Alice (19 January 2007). "The Brain: What the Mouse Brain Tells Us". Time.
  5. ^ Gordon, J. W.; Scangos, G. A.; Plotkin, D. J.; Barbosa, J. A.; Ruddle, F. H. (1980-12-01). "Genetic transformation of mouse embryos by microinjection of purified DNA". Proceedings of the National Academy of Sciences. 77 (12): 7380–7384. Bibcode:1980PNAS...77.7380G. doi:10.1073/pnas.77.12.7380. ISSN 0027-8424. PMC 350507. PMID 6261253.
  6. ^ Haruyama, Naoto; Cho, Andrew; Kulkarni, Ashok B. (2009). "Overview: Engineering Transgenic Constructs and Mice". Current Protocols in Cell Biology. 42 (1): 19.10.1–19.10.9. doi:10.1002/0471143030.cb1910s42. ISSN 1934-2616. PMC 2743315. PMID 19283728.