Moxidectin

Moxidectin
Structural formula of moxidectin
Ball-and-stick model of the moxidectin molecule
Clinical data
Trade namesCydectin, Equest, ProHeart, Quest.[1]
Other namesCL 301,423;[2] milbemycin B.[2]
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth, topical, subcutaneous
ATC code
Legal status
Legal status
Identifiers
  • (10E,14E,16E,22Z)-(1R,4S,5′S,6R,6′S,8R,13R,20R,21R,24S)-6′-
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.163.046 Edit this at Wikidata
Chemical and physical data
FormulaC37H53NO8
Molar mass639.830 g·mol−1
3D model (JSmol)
  • CC(C)\C=C(/C)[C@H]5O[C@@]2(C[C@H]1OC(=O)[C@@H]3/C=C(/C)[C@@H](O)[C@H]4OC/C(=C\C=C\[C@H](C)CC(\C)=C\C[C@H](C1)O2)[C@@]34O)C\C(=N\OC)[C@@H]5C
  • InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1 checkY
  • Key:YZBLFMPOMVTDJY-CBYMMZEQSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle, sheep and wombats.[4] Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.

  1. ^ Cite error: The named reference Awasthi 2013 was invoked but never defined (see the help page).
  2. ^ a b "milbemycin". MeSH - NCBI. Retrieved 21 July 2017.
  3. ^ "Cydectin Product information". Health Canada. 25 April 2012. Retrieved 29 May 2022.
  4. ^ Old JM, Skelton C, Stannard HJ (2021). "The use of Cydectin® by wildlife carers to treat sarcoptic mange in free-ranging bare-nosed wombats (Vombatus ursinus)". Parasitology Research. 120 (3): 1077–1090. doi:10.1007/s00436-020-07012-8. PMID 33438043.