Mr. E

Mr. E may refer to:

• Mister E, a DC Comics character and member of The Trenchcoat Brigade
• Mister E (Timely Comics), a Timely Comics (now Marvel Comics) character
• Mr. E (Ninjago), a character in Ninjago
• Mr. E, a character in the TV series Scooby-Doo! Mystery Incorporated
• Mark Oliver Everett (b. 1963), American lead vocalist and guitarist for Eels
• Nathan Ellery, a DC comics character who masterminded the murder of Alec Holland
• The ring name of professional wrestler Abe Zvonkin while masked
• "Mr. E,” a song by Red Velvet from the 2018 EP Summer Magic
• “Mr. E,” Meal, Ready-to-Eat one of the myriad plays on the acronym MRE within the military.