Mulholland or Mullholland ( mul-HOL-ənd) is a surname. Anglicized form of Gaelic Ó Maolchalann ‘descendant of Maolchalann’, a personal name meaning ‘chief of the calends’,
Notable people with the surname include:
- Alan Mulholland, Irish Gaelic footballer and manager
- Bob Mulholland, "senior advisor and longtime chief spokesperson" of the California Democratic Party
- Clara Mulholland (1849–1934), Irish writer
- Colm Mulholland, Irish Gaelic footballer
- Dale Mulholland, former US professional soccer player
- Danielle Mulholland, politician, Australia
- Frank Mulholland, Lord Mulholland PC KC (born 1959), Scottish judge
- Greg Mulholland, Liberal Democrat politician in the United Kingdom
- Inez Mullholland, suffragist, labor lawyer, World War I correspondent, and public speaker
- Jimmy Mulholland (born 1938), Scottish footballer
- Joe H. Mulholland, American politician
- Joan Trumpauer Mulholland, Civil Rights / integration activist
- John Mulholland (disambiguation), human name disambiguation page
- Peter Mulholland (c.1953–2021), Australian rugby league football coach
- Robert Mulholland, politician and businessman of Ontario
- Rosanne Mulholland, Brazilian actress
- St. Clair Augustine Mulholland, American Civil War colonel
- Terry Mulholland, former Major League Baseball pitcher
- Tom Mulholland (disambiguation), human name disambiguation page
- William Mulholland, civil engineer in Los Angeles circa 1900