Multidrug resistance-associated protein 2

ABCC2
Identifiers
Aliases	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP, Multidrug resistance-associated protein 2, ATP binding cassette subfamily C member 2
External IDs	OMIM: 601107; MGI: 1352447; HomoloGene: 68052; GeneCards: ABCC2; OMA:ABCC2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,852,594 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,829,179 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; jejunal mucosa; ; gallbladder; ; duodenum; ; human kidney; ; mucosa of ileum; ; testicle; ; tibial nerve; ; gonad; ; sural nerve;
	Top expressed in
	left lobe of liver; ; duodenum; ; right kidney; ; proximal tubule; ; jejunum; ; human kidney; ; yolk sac; ; epithelium of small intestine; ; ileum; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATPase activity; nucleotide binding; protein binding; ATP binding; transporter activity; protein domain specific binding; ATPase-coupled transmembrane transporter activity; organic anion transmembrane transporter activity; ATPase-coupled inorganic anion transmembrane transporter activity; bilirubin transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; cell surface; plasma membrane; apical plasma membrane; brush border membrane; intercellular canaliculus; integral component of plasma membrane;
Biological process	response to steroid hormone; response to arsenic-containing substance; prostaglandin transport; response to methotrexate; thyroid hormone transport; xenobiotic transmembrane transport; transmembrane transport; cellular chloride ion homeostasis; response to oxidative stress; response to estrogen; response to heat; bilirubin transport; female pregnancy; mercury ion transport; canalicular bile acid transport; antibiotic metabolic process; cellular response to lipopolysaccharide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to tumor necrosis factor; cellular response to dexamethasone stimulus; response to antineoplastic agent; benzylpenicillin metabolic process; cellular response to hormone stimulus; transport; organic anion transport; response to lipopolysaccharide; response to glucagon;
	Sources:Amigo / QuickGO
Orthologs
	1244
	12780
	ENSG00000023839
	ENSMUSG00000025194
	Q92887
	Q8VI47
	NM_000392
	NM_013806
	NP_000383
	NP_038834
	Wikidata
View/Edit Human	View/Edit Mouse

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000023839 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025194 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference pmid8797578 was invoked but never defined (see the help page).
^ Cite error: The named reference pmid9284939 was invoked but never defined (see the help page).
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000023839 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025194 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8797578-5] Cite error: The named reference pmid8797578 was invoked but never defined (see the help page).

[pmid9284939-6] Cite error: The named reference pmid9284939 was invoked but never defined (see the help page).

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

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