Myomegalin, also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2, is a protein that in humans is encoded by the PDE4DIP gene.[5][6][7] It has roles in the formation of microtubules from the centrosome.[8] Its name derives from the fact that it is highly expressed in units of tubular myofibrils known as sarcomeres and is a large protein, at 2,324 amino acids.[9] It was first characterised in 2000.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000178104 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038170 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, et al. (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
- ^ Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, et al. (April 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal of Biological Chemistry. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. hdl:11573/1681344. PMID 11134006.
- ^ "Entrez Gene: PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)".
- ^ Roubin R, Acquaviva C, Chevrier V, Sedjaï F, Zyss D, Birnbaum D, Rosnet O (February 2013). "Myomegalin is necessary for the formation of centrosomal and Golgi-derived microtubules". Biology Open. 2 (2): 238–50. doi:10.1242/bio.20123392. PMC 3575658. PMID 23430395.
- ^ a b Cite error: The named reference
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