Myomesin-2

MYOM2
Identifiers
Aliases	MYOM2, TTNAP, myomesin 2
External IDs	OMIM: 603509; MGI: 1328358; HomoloGene: 2953; GeneCards: MYOM2; OMA:MYOM2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.3 Start 2,045,046 bp[1] End 2,165,552 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 15,057,653 bp[2] End 15,133,541 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh right auricle left ventricle skeletal muscle tissue gastrocnemius muscle granulocyte Brodmann area 9 right frontal lobe testicle Top expressed in triceps brachii muscle sternocleidomastoid muscle temporal muscle muscle of thigh digastric muscle body of femur gastrocnemius muscle medial head of gastrocnemius muscle myocardium of ventricle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of muscle protein binding actin filament binding muscle alpha-actinin binding structural molecule activity conferring elasticity kinase binding Cellular component cytoplasm myosin filament mitochondrion muscle myosin complex Z discdkac M band striated muscle thin filament sarcomere Biological process muscle contraction extraocular skeletal muscle development striated muscle contraction actin filament organization sarcomere organization striated muscle myosin thick filament assembly skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly cardiac myofibril assembly cardiac muscle tissue morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9172 17930 Ensembl ENSG00000036448 ENSMUSG00000031461 UniProt P54296 n/a RefSeq (mRNA) NM_003970 NM_008664 RefSeq (protein) NP_003961 n/a Location (UCSC) Chr 8: 2.05 – 2.17 Mb Chr 8: 15.06 – 15.13 Mb PubMed search [3] [4]
Wikidata
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Myomesin-2, also known as M-protein is a protein that in humans is encoded by the MYOM2 gene.^[5] M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins comprising M-band structures in a sarcomere.