Myosin binding protein C, cardiac

MYBPC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GXE, 2AVG, 2K1M, 2MQ0, 2MQ3, 2V6H, 3CX2, 1PD6
Identifiers
Aliases	MYBPC3, CMD1MM, CMH4, FHC, LVNC10, MYBP-C, Myosin binding protein C, cardiac, cMyBP-C, myosin binding protein C3
External IDs	OMIM: 600958; MGI: 102844; HomoloGene: 215; GeneCards: MYBPC3; OMA:MYBPC3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,331,406 bp[1] End 47,352,702 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 90,948,489 bp[2] End 90,966,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right auricle myocardium of left ventricle right ventricle cardiac muscle tissue of right atrium vena cava testicle blood pericardium gonad Top expressed in myocardium of ventricle cardiac muscles right ventricle cardiac muscle tissue of left ventricle atrium interventricular septum endocardial cushion atrioventricular valve semi-lunar valve aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function myosin binding titin binding metal ion binding myosin heavy chain binding protein binding identical protein binding actin binding ATPase activator activity structural constituent of muscle actin filament binding muscle alpha-actinin binding structural molecule activity conferring elasticity Cellular component cytosol C zone sarcomere striated muscle myosin thick filament myosin filament A band Z discdkac M band cardiac myofibril striated muscle thin filament Biological process regulation of muscle filament sliding positive regulation of ATP-dependent activity cardiac muscle contraction heart morphogenesis ventricular cardiac muscle tissue morphogenesis regulation of striated muscle contraction cell adhesion muscle filament sliding striated muscle contraction actin filament organization sarcomere organization striated muscle myosin thick filament assembly muscle contraction skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly cardiac myofibril assembly cardiac muscle tissue morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4607 17868 Ensembl ENSG00000134571 ENSMUSG00000002100 UniProt Q14896 O70468 RefSeq (mRNA) NM_000256 NM_008653 RefSeq (protein) NP_000247 NP_000247.2 n/a Location (UCSC) Chr 11: 47.33 – 47.35 Mb Chr 2: 90.95 – 90.97 Mb PubMed search [3] [4]
Wikidata
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The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene.^[5] This isoform is expressed exclusively in heart muscle during human and mouse development,^[6] and is distinct from those expressed in slow skeletal muscle (MYBPC1) and fast skeletal muscle (MYBPC2).