N-Myc

MYCN
Identifiers
Aliases	MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYCNsPEP
External IDs	OMIM: 164840; MGI: 97357; HomoloGene: 3922; GeneCards: MYCN; OMA:MYCN - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.3 Start 15,940,550 bp[1] End 15,947,007 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 6.14 cM Start 12,986,094 bp[2] End 12,991,915 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo ganglionic eminence gonad placenta kidney tubule testicle middle temporal gyrus decidua Brodmann area 23 Top expressed in primitive streak epiblast hair follicle medial ganglionic eminence somite ventricular zone abdominal wall mandibular prominence maxillary prominence superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific kinase binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component chromatin nucleus nucleolus Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of gene expression negative regulation of gene expression positive regulation of production of miRNAs involved in gene silencing by miRNA transcription by RNA polymerase II cartilage condensation positive regulation of mesenchymal cell proliferation positive regulation of cell population proliferation positive regulation of cell death lung development embryonic digit morphogenesis regulation of inner ear auditory receptor cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic skeletal system morphogenesis negative regulation of astrocyte differentiation branching morphogenesis of an epithelial tube negative regulation of reactive oxygen species metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4613 18109 Ensembl ENSG00000134323 ENSMUSG00000037169 UniProt P04198 P03966 RefSeq (mRNA) NM_005378 NM_001293228 NM_001293231 NM_001293233 NM_008709 RefSeq (protein) NP_001280157 NP_001280160 NP_001280162 NP_005369 NP_032735 Location (UCSC) Chr 2: 15.94 – 15.95 Mb Chr 12: 12.99 – 12.99 Mb PubMed search [3] [4]
Wikidata
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N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.