NELL1

NELL1
Identifiers
Aliases	NELL1, IDH3GL, NRP1, neural EGFL like 1
External IDs	OMIM: 602319; MGI: 2443902; HomoloGene: 4486; GeneCards: NELL1; OMA:NELL1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	21,575,686 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	50,516,356 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; buccal mucosa cell; ; ventricular zone; ; orbitofrontal cortex; ; Brodmann area 46; ; middle temporal gyrus; ; prefrontal cortex; ; sperm; ; Brodmann area 10; ; superior frontal gyrus;
	Top expressed in
	medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; facial motor nucleus; ; suprachiasmatic nucleus; ; superior colliculus; ; ventral tegmental area; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; protein kinase C binding; heparin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; extracellular region; nuclear envelope; nucleus;
Biological process	regulation of gene expression; negative regulation of osteoblast proliferation; cell differentiation; positive regulation of osteoblast differentiation; nervous system development; positive regulation of bone mineralization;
	Sources:Amigo / QuickGO
Orthologs
	4745
	338352
	ENSG00000165973
	ENSMUSG00000055409
	Q92832
	Q2VWQ2
	NM_001288713; NM_001288714; NM_006157; NM_201551
	NM_001037906; NM_177413
	NP_001275642; NP_001275643; NP_006148; NP_963845
	NP_001032995
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165973 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055409 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E (Mar 1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics. 38 (3): 273–6. doi:10.1006/geno.1996.0628. PMID 8975702.
^ "Entrez Gene: NELL1 NEL-like 1 (chicken)".
^ "Study reveals bone-building protein's impact on bone stem cells".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165973 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055409 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8975702-5] Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E (Mar 1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics. 38 (3): 273–6. doi:10.1006/geno.1996.0628. PMID 8975702.

[entrez-6] "Entrez Gene: NELL1 NEL-like 1 (chicken)".

[medicalxpress-7] "Study reveals bone-building protein's impact on bone stem cells".

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