NEUROD2

NEUROD2
Identifiers
Aliases	NEUROD2, NDRF, bHLHa1, neuronal differentiation 2, EIEE72, DEE72
External IDs	OMIM: 601725; MGI: 107755; HomoloGene: 4489; GeneCards: NEUROD2; OMA:NEUROD2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,609,777 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,220,474 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right hemisphere of cerebellum; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; paraflocculus of cerebellum; ; hippocampus proper; ; prefrontal cortex; ; superior frontal gyrus;
	Top expressed in
	CA3 field; ; primary visual cortex; ; perirhinal cortex; ; entorhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; ventricular zone; ; superior frontal gyrus; ; Region I of hippocampus proper; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein dimerization activity; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	cellular response to calcium ion; regulation of neuron differentiation; cell differentiation; negative regulation of nucleic acid-templated transcription; positive regulation of calcium-mediated signaling; associative learning; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of DNA-binding transcription factor activity; neuron development; transcription by RNA polymerase II; behavioral fear response; transcription, DNA-templated; nervous system development; positive regulation of synaptic plasticity; negative regulation of synapse maturation; multicellular organism development; positive regulation of synapse maturation; protein ubiquitination; positive regulation of neuron differentiation; cerebellar cortex development; regulation of synapse maturation; positive regulation of transcription by RNA polymerase II; cellular response to electrical stimulus;
	Sources:Amigo / QuickGO
Orthologs
	4761
	18013
	ENSG00000171532
	ENSMUSG00000038255
	Q15784
	Q62414
	NM_006160
	NM_010895
	NP_006151
	NP_035025
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171532 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
^ "Entrez Gene: NEUROD2 neurogenic differentiation 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171532 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038255 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119405-5] Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.

[entrez-6] "Entrez Gene: NEUROD2 neurogenic differentiation 2".

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