NFAT5

NFAT5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IMH
Identifiers
Aliases	NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP, nuclear factor of activated T-cells 5, tonicity-responsive, nuclear factor of activated T-cells 5, nuclear factor of activated T cells 5
External IDs	OMIM: 604708; MGI: 1859333; HomoloGene: 4811; GeneCards: NFAT5; OMA:NFAT5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,565,094 bp[1] End 69,704,666 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.93 cM Start 108,020,102 bp[2] End 108,106,149 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla nipple caput epididymis corpus epididymis tail of epididymis Achilles tendon saphenous vein epithelium of colon lactiferous duct vena cava Top expressed in ascending aorta aortic valve gastrula medullary collecting duct adrenal gland skin of external ear trachea habenula vestibular membrane of cochlear duct umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding transcription factor binding Cellular component nucleus nucleoplasm cytoplasm cytosol transcription regulator complex Biological process regulation of calcineurin-NFAT signaling cascade cytokine production positive regulation of gene expression excretion regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated signal transduction positive regulation of transcription by RNA polymerase II calcineurin-NFAT signaling cascade response to osmotic stress cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10725 54446 Ensembl ENSG00000102908 ENSMUSG00000003847 UniProt O94916 Q9WV30 RefSeq (mRNA) NM_001113178 NM_006599 NM_138713 NM_138714 NM_173214 NM_173215 NM_001367709 NM_001286260 NM_018823 NM_133957 RefSeq (protein) NP_001106649 NP_006590 NP_619727 NP_619728 NP_775321 NP_775322 NP_001354638 NP_001273189 NP_061293 NP_598718 Location (UCSC) Chr 16: 69.57 – 69.7 Mb Chr 8: 108.02 – 108.11 Mb PubMed search [3] [4]
Wikidata
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Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress.^[5]

The product of this gene is a member of the nuclear factors of activated T cells (NFAT) family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]