NFATC4

NFATC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YRP
Identifiers
Aliases	NFATC4, NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4
External IDs	OMIM: 602699; MGI: 1920431; HomoloGene: 3349; GeneCards: NFATC4; OMA:NFATC4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,379,604 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,071,400 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; right ovary; ; left ovary; ; stromal cell of endometrium; ; body of uterus; ; left uterine tube; ; myometrium; ; gastric mucosa; ; muscle layer of sigmoid colon; ; right coronary artery;
	Top expressed in
	gastrula; ; external carotid artery; ; internal carotid artery; ; genital tubercle; ; maxillary prominence; ; mandibular prominence; ; ventricular zone; ; hand; ; calvaria; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; peroxisome proliferator activated receptor binding; chromatin binding;
Cellular component	transcription regulator complex; nucleus; cytoplasm; cytosol; nuclear speck;
Biological process	cell differentiation; regulation of transcription, DNA-templated; cellular response to lithium ion; negative regulation of chromatin binding; cellular response to UV; negative regulation of Wnt signaling pathway; calcineurin-NFAT signaling cascade; positive regulation of apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of protein binding; smooth muscle cell differentiation; transcription, DNA-templated; regulation of synaptic plasticity; negative regulation of synapse maturation; heart development; negative regulation of dendrite morphogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of tumor necrosis factor production; branching involved in blood vessel morphogenesis; cellular respiration; positive regulation of apoptotic process; inflammatory response; muscle cell development; positive regulation of transcription by RNA polymerase II; negative regulation of pri-miRNA transcription by RNA polymerase II; cellular response to ionomycin; cytokine production; long-term memory; brain-derived neurotrophic factor receptor signaling pathway; negative regulation of neuron apoptotic process; long-term potentiation; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	4776
	73181
	ENSG00000100968; ENSG00000285485
	ENSMUSG00000023411
	Q14934
	Q8K120
NM_001136022; NM_001198965; NM_001198966; NM_001198967; NM_001288802;
	NM_004554; NM_001320043; NM_001363681; NM_001363682
	NM_001168346; NM_023699
NP_001129494; NP_001185894; NP_001185895; NP_001185896; NP_001275731;
	NP_001306972; NP_004545; NP_001350610; NP_001350611
	NP_001161818; NP_076188
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000285485 GRCh38: Ensembl release 89: ENSG00000100968, ENSG00000285485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023411 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
^ "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".

[refGRCh38Ensembl-1] ENSG00000285485 GRCh38: Ensembl release 89: ENSG00000100968, ENSG00000285485 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023411 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7749981-5] Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.

[entrez-6] "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".

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