NFE2L1

NFE2L1
Identifiers
AliasesNFE2L1, LCR-F1, NRF1, TCF11, nuclear factor, erythroid 2 like 1, NRF-1, NFE2 like bZIP transcription factor 1
External IDsOMIM: 163260; MGI: 99421; HomoloGene: 20685; GeneCards: NFE2L1; OMA:NFE2L1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003204
NM_001330261
NM_001330262

RefSeq (protein)

NP_001317190
NP_001317191
NP_003195

Location (UCSC)Chr 17: 48.05 – 48.06 MbChr 11: 96.71 – 96.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene.[5][6][7] Since NFE2L1 is referred to as Nrf1, it is often confused with nuclear respiratory factor 1 (Nrf1).

NFE2L1 is a cap ‘n’ collar, basic-leucine zipper (bZIP) transcription factor. Several isoforms of NFE2L1 have been described for both human and mouse genes. NFE2L1 was first cloned in yeast using a genetic screening method. NFE2L1 is ubiquitously expressed, and high levels of transcript are detected in the heart, kidney, skeletal muscle, fat, and brain.[5] Four separate regions — an asparagine/serine/threonine, acidic domains near the N-terminus, and a serine-rich domain located near the CNC motif — are required for full transactivation function of NFE2L1.[8][9][10] NFE2L1 is a key regulator of cellular functions including oxidative stress response, differentiation, inflammatory response, metabolism, cholesterol handling[11] and maintaining proteostasis.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082641Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038615Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Chan JY, Han XL, Kan YW (Dec 1993). "Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (23): 11371–5. Bibcode:1993PNAS...9011371C. doi:10.1073/pnas.90.23.11371. PMC 47984. PMID 8248256.
  6. ^ Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TS, Kan YW (Mar 1998). "Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice". The EMBO Journal. 17 (6): 1779–87. doi:10.1093/emboj/17.6.1779. PMC 1170525. PMID 9501099.
  7. ^ "Entrez Gene: NFE2L1 nuclear factor (erythroid-derived 2)-like 1".
  8. ^ Husberg C, Murphy P, Martin E, Kolsto AB (May 2001). "Two domains of the human bZIP transcription factor TCF11 are necessary for transactivation" (PDF). The Journal of Biological Chemistry. 276 (21): 17641–52. doi:10.1074/jbc.M007951200. PMID 11278371. S2CID 26136436.
  9. ^ Zhang Y, Lucocq JM, Hayes JD (Mar 2009). "The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors" (PDF). The Biochemical Journal. 418 (2): 293–310. doi:10.1042/BJ20081575. PMID 18990090.
  10. ^ Wang W, Kwok AM, Chan JY (Aug 2007). "The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription". The Journal of Biological Chemistry. 282 (34): 24670–8. doi:10.1074/jbc.M700159200. PMID 17609210.
  11. ^ Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS (November 2017). "NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis". Cell. 171 (5): 1094–1109.e15. doi:10.1016/j.cell.2017.10.003. PMID 29149604.