NFYB

NFYB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N1J, 4AWL, 4CSR
Identifiers
Aliases	NFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDs	OMIM: 189904; MGI: 97317; HomoloGene: 38149; GeneCards: NFYB; OMA:NFYB - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	104,138,241 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	82,599,978 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; ventricular zone; ; endothelial cell; ; right coronary artery; ; seminal vesicula; ; left coronary artery; ; tibial arteries; ; Descending thoracic aorta; ; muscle layer of sigmoid colon;
	Top expressed in
	primitive streak; ; epiblast; ; ganglionic eminence; ; saccule; ; otic vesicle; ; embryo; ; ventricular zone; ; maxillary prominence; ; Rostral migratory stream; ; Region I of hippocampus proper;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; protein binding; protein heterodimerization activity; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding;
Cellular component	protein-DNA complex; nucleoplasm; CCAAT-binding factor complex; nucleus; RNA polymerase II transcription regulator complex;
Biological process	positive regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of cholesterol biosynthetic process; cellular response to leukemia inhibitory factor; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4801
	18045
	ENSG00000120837
	ENSMUSG00000020248
	P25208
	P63139
	NM_006166
	NM_010914
	NP_006157; NP_006157.1
	NP_035044
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120837 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020248 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067.
^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120837 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020248 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1774067-5] Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067.

[pmid9612081-6] Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081.

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