NKX3-1

NKX3-1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L9R
Identifiers
Aliases	NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A, NK3 homeobox 1
External IDs	OMIM: 602041; MGI: 97352; HomoloGene: 4494; GeneCards: NKX3-1; OMA:NKX3-1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 23,678,697 bp[1] End 23,682,938 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D2|14 36.02 cM Start 69,428,087 bp[2] End 69,432,111 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva secondary oocyte sperm prostate trachea germinal epithelium urethra testicle mucosa of nose minor salivary glands Top expressed in prostatic epithelium vasculature of trunk urethral gland (male) bulbo-urethral gland descending aorta renal artery dorsal aorta anterior lobe of prostate gastrula incisor More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity transcription factor binding histone deacetylase binding transcription cis-regulatory region binding RNA polymerase II general transcription initiation factor activity estrogen receptor activity protein kinase activator activity protein self-association MADS box domain binding protein binding cysteine-type endopeptidase activator activity involved in apoptotic process estrogen receptor binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity Cellular component intracellular anatomical structure nucleus site of DNA damage Biological process somitogenesis androgen receptor signaling pathway cellular response to steroid hormone stimulus dorsal aorta development positive regulation of protein phosphorylation male gonad development positive regulation of cell death regulation of transcription, DNA-templated protein kinase B signaling response to testosterone epithelial cell proliferation involved in salivary gland morphogenesis cellular response to tumor necrosis factor positive regulation of androgen secretion positive regulation of mitotic cell cycle positive regulation of apoptotic signaling pathway prostate gland development negative regulation of gene expression transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated salivary gland development heart development positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of gene expression positive regulation of response to DNA damage stimulus branching involved in prostate gland morphogenesis negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of cell population proliferation cellular response to interleukin-1 negative regulation of epithelial cell proliferation negative regulation of insulin-like growth factor receptor signaling pathway urogenital system development positive regulation of phosphatidylinositol 3-kinase signaling metanephros development negative regulation of transcription, DNA-templated activation of cysteine-type endopeptidase activity involved in apoptotic process branching morphogenesis of an epithelial tube positive regulation of intrinsic apoptotic signaling pathway positive regulation of cell division cellular response to hypoxia positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of mitotic cell cycle pharyngeal system development activation of protein kinase activity regulation of protein localization positive regulation of DNA-binding transcription factor activity cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4824 18095 Ensembl ENSG00000167034 ENSMUSG00000022061 UniProt Q99801 P97436 RefSeq (mRNA) NM_001256339 NM_006167 NM_010921 RefSeq (protein) NP_001243268 NP_006158 NP_035051 Location (UCSC) Chr 8: 23.68 – 23.68 Mb Chr 14: 69.43 – 69.43 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p.^[5] NKX3-1 is a prostatic tumor suppressor gene.

NKX3-1 is an androgen-regulated, prostate-specific homeobox gene whose expression is predominantly localized to prostate epithelium. It acts as a transcription factor that has critical function in prostate development and tumor suppression. It is a negative regulator of epithelial cell growth in prostate tissue. The NKX3-1 homeobox protein is encoded by the NKX3-1 gene.^[5]