NLRP5

NLRP5
Identifiers
Aliases	NLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5
External IDs	OMIM: 609658; MGI: 1345193; HomoloGene: 65105; GeneCards: NLRP5; OMA:NLRP5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,061,810 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	23,141,347 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; gonad; ; endometrium; ; gastric mucosa; ; anterior pituitary; ; ovary; ; right ovary; ; myeloid leukocyte; ; monocyte;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; egg cell; ; ovary; ; morula; ; fossa; ; seminiferous tubule; ; spermatid; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATP binding;
Cellular component	cytoplasm; nucleolus; mitochondrion; nucleus;
Biological process	neuron death;
	Sources:Amigo / QuickGO
Orthologs
	126206
	23968
	ENSG00000171487
	ENSMUSG00000015721
	P59047
	Q9R1M5
	NM_153447
	NM_001039143; NM_011860; NM_001305857
	NP_703148
	NP_001034232; NP_001292786; NP_035990
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.^[5]^[6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.

In humans, the NLRP5 protein is encoded by the NLRP5 gene.^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171487 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015721 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779.
^ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. doi:10.1262/jrd.09-098a. PMID 19815987.
^ "Entrez Gene: NLR family".
^ Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. doi:10.1093/humrep/17.4.903. PMID 11925379.
^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171487 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015721 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19054779-5] Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779.

[pmid19815987-6] Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. doi:10.1262/jrd.09-098a. PMID 19815987.

[entrez-7] "Entrez Gene: NLR family".

[pmid11925379-8] Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. doi:10.1093/humrep/17.4.903. PMID 11925379.

[pmid12563287-9] Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]