NME1

NME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JXV, 1UCN, 2HVD, 2HVE, 3L7U, 4ENO
Identifiers
Aliases	NME1, AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1, NME/NM23 nucleoside diphosphate kinase 1
External IDs	OMIM: 156490; MGI: 97355; HomoloGene: 128514; GeneCards: NME1; OMA:NME1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	51,162,428 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	93,859,347 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; hypothalamus; ; Brodmann area 9; ; superior frontal gyrus; ; islet of Langerhans; ; ganglionic eminence; ; right frontal lobe; ; hippocampus proper; ; primary visual cortex; ; cingulate gyrus;
	Top expressed in
	right kidney; ; epiblast; ; neural tube; ; proximal tubule; ; embryo; ; embryo; ; ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; morula; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; deoxyribonuclease activity; ribosomal small subunit binding; GTP binding; metal ion binding; kinase activity; protein binding; identical protein binding; ATP binding; magnesium ion binding; nucleoside diphosphate kinase activity; RNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; single-stranded DNA binding; intermediate filament binding; enzyme binding; protein kinase binding; gamma-tubulin binding;
Cellular component	ruffle membrane; extracellular exosome; nucleus; cytoplasm; mitochondrial outer membrane; centrosome; cytosol; intermediate filament; membrane; perinuclear region of cytoplasm; mitochondrion; myelin sheath;
Biological process	UTP biosynthetic process; regulation of apoptotic process; cell differentiation; nucleobase-containing small molecule interconversion; CTP biosynthetic process; endocytosis; phosphorylation; positive regulation of epithelial cell proliferation; nucleotide metabolic process; nucleoside diphosphate phosphorylation; nervous system development; positive regulation of DNA binding; GTP biosynthetic process; negative regulation of cell population proliferation; DNA metabolic process; negative regulation of myeloid leukocyte differentiation; negative regulation of gene expression; positive regulation of neuron projection development; response to amine; hippocampus development; response to testosterone; response to cAMP; cellular response to glucose stimulus; cellular response to fatty acid; lactation; mammary gland development;
	Sources:Amigo / QuickGO
Orthologs
	4830
	18102
	ENSG00000239672
	ENSMUSG00000037601
	P15531
	P15532
	NM_198175; NM_000269
	NM_008704; NM_001378854
	NP_000260; NP_937818
	NP_032730; NP_001365783
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene.^[5] It is thought to be a metastasis suppressor.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000239672 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037601 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C (February 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet. 93 (1): 63–6. doi:10.1007/bf00218915. PMID 8270257. S2CID 6373221.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000239672 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037601 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8270257-5] Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C (February 1994). "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1". Hum. Genet. 93 (1): 63–6. doi:10.1007/bf00218915. PMID 8270257. S2CID 6373221.

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