NOX2

CYBB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A1F
Identifiers
Aliases	CYBB, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX, cytochrome b-245 beta chain, CGDX
External IDs	OMIM: 300481; MGI: 88574; HomoloGene: 68054; GeneCards: CYBB; OMA:CYBB - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp21.1-p11.4 Start 37,780,018 bp[1] End 37,813,461 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 9,301,491 bp[2] End 9,354,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte bone marrow bone marrow cells synovial joint blood trabecular bone appendix lymph node decidua Top expressed in granulocyte stroma of bone marrow mesenteric lymph nodes right lung lobe spleen lumbar spinal ganglion tibiofemoral joint calvaria blood ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function flavin adenine dinucleotide binding superoxide-generating NAD(P)H oxidase activity metal ion binding voltage-gated ion channel activity protein binding heme binding protein heterodimerization activity electron transfer activity oxidoreductase activity Cellular component cytoplasm integral component of membrane phagocytic vesicle membrane membrane plasma membrane integral component of plasma membrane NADPH oxidase complex perinuclear region of cytoplasm phagocytic vesicle Golgi apparatus endoplasmic reticulum soma intracellular anatomical structure endoplasmic reticulum membrane rough endoplasmic reticulum dendrite nuclear envelope specific granule membrane tertiary granule membrane perinuclear endoplasmic reticulum Biological process regulation of ion transmembrane transport ion transport superoxide anion generation respiratory burst vascular endothelial growth factor receptor signaling pathway hydrogen peroxide biosynthetic process innate immune response inflammatory response superoxide metabolic process cellular response to L-glutamine positive regulation of angiogenesis response to angiotensin response to nutrient cellular response to hypoxia hypoxia-inducible factor-1alpha signaling pathway cellular response to cadmium ion cellular response to ethanol response to aldosterone neutrophil degranulation cellular response to oxidative stress electron transport chain ion transmembrane transport antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent defense response cell redox homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1536 13058 Ensembl ENSG00000165168 ENSMUSG00000015340 UniProt P04839 Q61093 RefSeq (mRNA) NM_000397 NM_007807 RefSeq (protein) NP_000388 NP_031833 Location (UCSC) Chr X: 37.78 – 37.81 Mb Chr X: 9.3 – 9.35 Mb PubMed search [3] [4]
Wikidata
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NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene).^[5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).