NRL (gene)

NRL
Identifiers
Aliases	NRL, D14S46E, NRL-MAF, RP27, neural retina leucine zipper
External IDs	OMIM: 162080; MGI: 102567; HomoloGene: 4501; GeneCards: NRL; OMA:NRL - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,115,010 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,762,438 bp
RNA expression pattern
	Top expressed in
	testicle; ; muscle of thigh; ; right lobe of liver; ; granulocyte; ; C1 segment; ; prefrontal cortex; ; gonad; ; apex of heart; ; human kidney; ; amygdala;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; epithelium of lens; ; outer nuclear layer; ; ciliary body; ; iris; ; cornea; ; conjunctival fornix; ; ganglion cell layer; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; leucine zipper domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; promoter-specific chromatin binding; transcription coactivator activity; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; cytosol; nucleus; cytoplasm;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; visual perception; response to stimulus; retinal rod cell development; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4901
	18185
	ENSG00000129535; ENSG00000285493
	ENSMUSG00000040632
	P54845
	P54846
	NM_006177; NM_001354768; NM_001354769; NM_001354770
	NM_001136074; NM_001271916; NM_001271917; NM_008736
	NP_006168; NP_001341697; NP_001341698; NP_001341699
	NP_001129546; NP_001258845; NP_001258846; NP_032762
	Wikidata
View/Edit Human	View/Edit Mouse

Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000285493 GRCh38: Ensembl release 89: ENSG00000129535, ENSG00000285493 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040632 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang-Feng TL, Swaroop A (Oct 1992). "Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2" (PDF). Genomics. 14 (2): 491–2. doi:10.1016/S0888-7543(05)80248-4. hdl:2027.42/29820. PMID 1427865.
^ Bessant DA, Payne AM, Mitton KP, Wang QL, Swain PK, Plant C, Bird AC, Zack DJ, Swaroop A, Bhattacharya SS (Apr 1999). "A mutation in NRL is associated with autosomal dominant retinitis pigmentosa". Nature Genetics. 21 (4): 355–6. doi:10.1038/7678. PMID 10192380. S2CID 28621258.
^ "Entrez Gene: NRL neural retina leucine zipper".

[refGRCh38Ensembl-1] ENSG00000285493 GRCh38: Ensembl release 89: ENSG00000129535, ENSG00000285493 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040632 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427865-5] Yang-Feng TL, Swaroop A (Oct 1992). "Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2" (PDF). Genomics. 14 (2): 491–2. doi:10.1016/S0888-7543(05)80248-4. hdl:2027.42/29820. PMID 1427865.

[pmid10192380-6] Bessant DA, Payne AM, Mitton KP, Wang QL, Swain PK, Plant C, Bird AC, Zack DJ, Swaroop A, Bhattacharya SS (Apr 1999). "A mutation in NRL is associated with autosomal dominant retinitis pigmentosa". Nature Genetics. 21 (4): 355–6. doi:10.1038/7678. PMID 10192380. S2CID 28621258.

[entrez-7] "Entrez Gene: NRL neural retina leucine zipper".

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