NT5C3

NT5C3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CN1, 2JGA, 2VKQ
Identifiers
Aliases	NT5C3A, NT5C3, P5'N-1, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1, cN-III, hUMP1, p36, 5'-nucleotidase, cytosolic IIIA
External IDs	OMIM: 606224; MGI: 1927186; HomoloGene: 9534; GeneCards: NT5C3A; OMA:NT5C3A - orthologs
EC number	3.1.3.91
Gene location (Human)
Chr.	Chromosome 7 (human)
End	33,062,797 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	56,900,917 bp
RNA expression pattern
	Top expressed in
	quadriceps femoris muscle; ; monocyte; ; thymus; ; rectum; ; duodenum; ; gastrocnemius muscle; ; muscle of thigh; ; islet of Langerhans; ; mucosa of transverse colon; ; cerebellar vermis;
	Top expressed in
	blood; ; interventricular septum; ; islet of Langerhans; ; esophagus; ; right kidney; ; soleus muscle; ; left colon; ; spleen; ; temporal muscle; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; 5'-nucleotidase activity; hydrolase activity; magnesium ion binding; metal ion binding; tRNA 2'-phosphotransferase activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum;
Biological process	pyrimidine nucleoside metabolic process; adenosine metabolic process; nucleotide metabolic process; pyrimidine nucleoside catabolic process; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	51251
	107569
	ENSG00000122643
	ENSMUSG00000029780
	Q9H0P0
	Q9D020
	NM_001002009; NM_001002010; NM_001166118; NM_016489; NM_001356996
	NM_001252374; NM_026004; NM_001360963
NP_001002009; NP_001002010; NP_001159590; NP_057573; NP_001343925;
	NP_001361264; NP_001361265; NP_001361266; NP_001361267; NP_001361268
	NP_001239303; NP_080280; NP_001347892
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic 5'-nucleotidase 3 (NTC53), also known as cytosolic 5'-nucleotidase 3A, pyrimidine 5’-nucleotidase (PN-I or P5'NI), and p56, is an enzyme that in humans is encoded by the NT5C3, or NT5C3A, gene on chromosome 7.^[5]^[6]^[7]^[8]

This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122643 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029780 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
^ Amici A, Emanuelli M, Raffaelli N, Ruggieri S, Saccucci F, Magni G (Sep 2000). "Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon". Blood. 96 (4): 1596–8. doi:10.1182/blood.V96.4.1596. PMID 10942414.
^ ^a ^b "Entrez Gene: NT5C3 5'-nucleotidase, cytosolic III".
^ Amici A, Magni G (15 January 2002). "Human erythrocyte pyrimidine 5'-nucleotidase, PN-I". Archives of Biochemistry and Biophysics. 397 (2): 184–90. doi:10.1006/abbi.2001.2676. PMID 11795870.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122643 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029780 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[pmid10942414-6] Amici A, Emanuelli M, Raffaelli N, Ruggieri S, Saccucci F, Magni G (Sep 2000). "Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon". Blood. 96 (4): 1596–8. doi:10.1182/blood.V96.4.1596. PMID 10942414.

[entrez-7] "Entrez Gene: NT5C3 5'-nucleotidase, cytosolic III".

[pmid11795870-8] Amici A, Magni G (15 January 2002). "Human erythrocyte pyrimidine 5'-nucleotidase, PN-I". Archives of Biochemistry and Biophysics. 397 (2): 184–90. doi:10.1006/abbi.2001.2676. PMID 11795870.

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