Nucleotide-binding protein 2 (NBP 2) also known as cytosolic Fe-S cluster assembly factor NUBP2 is a protein that in humans is encoded by the NUBP2gene.[5]
NUBP2 is a member of the NUBP/MRP gene subfamily of ATP-binding proteins.[6] There are two types in eukaryotesNUBP1 and NUBP2, and one novel human gene that define NBP nucleotide-binding proteins (NUBP/MRP-multidrug resistance-associated protein)[5] in mammalian cells requires the maturation of cytosolic[7] iron-sulfur (Fe/S)[8] proteins as Nubp1 is involved in the formation of extramitochondrial Fe/S proteins[6] the cell division inhibitor MinD is homologous[9] and involve two proteins components of the (FeS) protein assembly machinery closely similar cytosolic[6] soluble[8]P loop[9]NTPase where Nar1[10][11] is required for assembly,[12] identified Cfd1p[13][14] in cytosolic and nuclear Fe/S protein biogenesis[8] in yeast.[15] Nubp proteins NTPase Nbp35p.[11][12]MinD is homologous to members in MinD of E. coli, a relative of the ParA family.[9][16][17]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abNakashima H, Grahovac MJ, Mazzarella R, et al. (1999). "Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes". Genomics. 60 (2): 152–60. doi:10.1006/geno.1999.5898. PMID10486206.
^Netz DJ, Pierik AJ, Stümpfig M, Mühlenhoff U, Lill R (2007). "The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol". Nat Chem Biol. 3 (5): 278–86. doi:10.1038/nchembio872. PMID17401378.
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