| NUT carcinoma (NC) | |
|---|---|
| Other names | NUT midline carcinoma (NMC)[1] |
 | |
| Micrograph of a NUT carcinoma with the characteristic well-differentiated islands of squamous epithelium. H&E stain. | |
| Specialty | Oncology |
NUT carcinoma (NC; formerly NUT midline carcinoma (NMC)) is a rare genetically defined, very aggressive squamous cell epithelial cancer that usually arises in the midline of the body and is characterized by a chromosomal rearrangement in the nuclear protein in testis gene (i.e. NUTM1 gene).[2] In approximately 75% of cases, the coding sequence of NUTM1 in band 14 on the long (or "q") arm of chromosome 15 is fused to BRD4 or BRD3, which creates a chimeric gene that encodes the BRD-NUT fusion protein. The remaining cases, the fusion of NUTM1 is to an unknown partner gene, usually called NUT-variant.
The name NUT carcinoma was introduced as the carcinoma does not only occur in the body midline; therefore, WHO also changed the name in 2015 in the WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart.[3]
- ^ RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: NUT midline carcinoma". www.orpha.net. Retrieved 18 November 2019.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ Online Mendelian Inheritance in Man (OMIM): 608963
- ^ International Agency for Research on Cancer (2015). WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. William D. Travis, Elisabeth Brambilla, Allen Burke, Alexander Marx, Andrew G. Nicholson (4th ed.). Lyon. ISBN 978-92-832-2436-5. OCLC 898924651.
{{cite book}}: CS1 maint: location missing publisher (link)