Nancy Bonini

Nancy M. Bonini
Born1959 (age 64–65)[4]
NationalityAmerican
Alma materPrinceton University (AB)

University of Wisconsin-Madison (PhD)

California Institute of Technology (Postdoc)
Known forDeveloped the first Drosophila model of human neurodenerative disease
SpouseAnthony Cashmore
Awards
Scientific career
Fields
InstitutionsUniversity of Pennsylvania
Doctoral advisorDavid L. Nelson
Websitehttp://web.sas.upenn.edu/bonini-lab/

Nancy M. Bonini (born 1959) is an American neuroscientist and geneticist, best known for pioneering the use of Drosophila as a model organism to study neurodegeneration of the human brain. Using the Drosophila model approach, Bonini's laboratory has identified genes and pathways that are important in the development and progression of neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's Disease),[5] Alzheimer's disease,[6] and Parkinson's disease,[7][8] as well as aging, neural injury and regeneration,[9] and response to environmental toxins.[8]

A professor of biology at the University of Pennsylvania since 1994, Bonini has held appointments as the inaugural Lucille B. Williams Term Professor of Biology (2006–2012),[10] an Investigator of the Howard Hughes Medical Institute (2000–2013),[1][11] and the Florence RC Murray Professor of Biology (since 2012).[12] She was editor of the Annual Review of Genetics from 2018-2021.[13][14]

  1. ^ a b "Our Investigators: Nancy M. Bonini, PhD". hhmi.org. Howard Hughes Medical Institute. 2019. Retrieved 15 Jul 2019.
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  5. ^ "DC: New ALS Genetics Hog the Limelight at Satellite Conference". www.alzforum.org. FBRI LLC. 2011. Retrieved 21 Jul 2019.
  6. ^ "Penn Study Shows that the "Epigenetic Landscape" is Protective in Normal Aging, Impaired in Alzheimer's Disease". Penn Medicine News. USA. 5 Mar 2018. Retrieved 19 Jul 2019.
  7. ^ Whitworth, Alexander; Wes, Paul D.; Pallanck, Leo J. (2006). "Drosophila models pioneer a new approach to drug discovery for Parkinson's disease" (PDF). Drug Discovery Today. 11 (3/4): 119–. doi:10.1016/S1359-6446(05)03693-7. PMID 16533709. Retrieved 20 Jul 2019.
  8. ^ a b "Drosophila Define DJ-1's Defensive Role". www.alzforum.org. FBRI LLC. 16 Dec 2005. Retrieved 21 Jul 2019.
  9. ^ Ugur, Berrack; Chen, Kuchuan; Bellen, Hugo J. (2016). "Drosophila tools and assays for the study of human diseases". Disease Models and Mechanisms. 9 (3): 235–244. doi:10.1242/dmm.023762. PMC 4833332. PMID 26935102. Retrieved 21 Jul 2019. The recently developed Drosophila wing injury assay is an elegant approach to study axonal degeneration and regeneration in vivo (Fang et al., 2012). The goal of these studies is to identify genes that are required for axonal degeneration and regeneration, and to identify the regulatory processes that are involved in spinal cord and nerve injuries.
  10. ^ "Science Professors to Four Chairs" (PDF). www.almanac.upenn.edu. University of Pennsylvania. 1 May 2007. Retrieved 20 Jul 2019.
  11. ^ "HHMI Scientists Elected to National Academy of Sciences in 2012". www.hhmi.org. Howard Hughes Medical Institute. 1 May 2012.
  12. ^ "Dr. Nancy Bonini appointed as the Florence R.C. Murray Professor of Biology". www.bio.upenn.edu. University of Pennsylvania. 8 Aug 2012. Retrieved 20 Jul 2019.
  13. ^ "EDITOR OF THE ANNUAL REVIEW OF GENETICS - VOLUME 52, 2018". Annual Reviews. Retrieved 29 July 2021.
  14. ^ "EDITOR OF THE ANNUAL REVIEW OF GENETICS - VOLUME 55, 2021". Annual Reviews. Retrieved 9 February 2022.