Nepafenac

Nepafenac
Clinical data
Trade namesNevanac, Ilevro, Amnac, others
AHFS/Drugs.comMonograph
MedlinePlusa606007
License data
Pregnancy
category
Routes of
administration		Topical eye drops
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)[2]
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
  • 2-amino-3-benzoylbenzeneacetamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.207.414 Edit this at Wikidata
Chemical and physical data
FormulaC15H14N2O2
Molar mass254.289 g·mol−1
3D model (JSmol)
  • O=C(c1cccc(c1N)CC(=O)N)c2ccccc2
  • InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) checkY
  • Key:QEFAQIPZVLVERP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution (Nevanac) or 0.3% solution (Ilevro). It is used to treat pain and inflammation associated with cataract surgery.[3] Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.[4][5]

  1. ^ "Nepafenac ophthalmic Use During Pregnancy". Drugs.com. 6 June 2019. Retrieved 13 September 2020.
  2. ^ "Prescription medicines: registration of new chemical entities in Australia, 2015". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  3. ^ Nepafenac Monograph
  4. ^ Drugbank: Nepafenac
  5. ^ Zanetti FR, Fulco EA, Chaves FR, da Costa Pinto AP, Arieta CE, Lira RP (July 2012). "Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: a randomized trial". Indian Journal of Ophthalmology. 60 (4): 277–81. doi:10.4103/0301-4738.98705. PMC 3442462. PMID 22824596.