Nerve growth factor

NGF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNGF, Beta-HSAN5, NGFB, nerve growth factor
External IDsOMIM: 162030; MGI: 97321; HomoloGene: 1876; GeneCards: NGF; OMA:NGF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002506

NM_001112698
NM_013609

RefSeq (protein)

NP_002497

NP_001106168
NP_038637

Location (UCSC)Chr 1: 115.29 – 115.34 MbChr 3: 102.38 – 102.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134259Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027859Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.