Netrin 1

NTN1
Available structures
PDBOrtholog search: O95631 PDBe O95631 RCSB
Identifiers
AliasesNTN1, NTN1L, netrin 1, MRMV4
External IDsOMIM: 601614; MGI: 105088; HomoloGene: 21008; GeneCards: NTN1; OMA:NTN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004822

NM_008744

RefSeq (protein)

NP_004813

NP_032770

Location (UCSC)Chr 17: 9.02 – 9.24 MbChr 11: 68.1 – 68.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[5][6]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065320Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020902Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (January 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
  6. ^ a b "Entrez Gene: NTN1 netrin 1".